I. Summary

SecReT6 ID	847
Strain	Vibrio campbellii ATCC BAA-1116
Replicon	chromosome II [Browse all T6SS(s) in this replicon]
Accession	NC_022270
Location	1007964..1037336
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	2	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	M892_22355	1006349..1007977 [-], 1629	541870623	T6SS/sigma-54-dependent transcriptional regulator VasH
2	M892_22360	1007964..1010648 [-], 2685	541870624	T6SS/ATPase, ClpA/B (ClpV1 family) VasG	TssH
3	M892_22365	1011098..1011616 [+], 519	541870625	T6SS/hemolysin co-regulated protein Hcp	TssD
4	M892_22370	1011689..1013767 [+], 2079	541870626	T6SS/ secreted protein VgrG	TssI
5	M892_22375	1013767..1014252 [+], 486	541870627	hypothetical protein
6	M892_22380	1014354..1015673 [+], 1320	541870628	hypothetical protein
7	M892_22385	1015654..1016646 [+], 993	541870629	hypothetical protein
8	M892_22390	1016639..1017583 [+], 945	541870630	hypothetical protein
9	M892_22395	1017819..1019822 [+], 2004	541871695	T6SS/serine-threonine protein kinase TagE
10	M892_22400	1019822..1021423 [+], 1602	541870631	T6SS/ImpA domain protein VasJ	TssA
11	M892_22405	1021450..1021956 [+], 507	541870632	T6SS/protein (ImpB family) VasQ	TssB
12	M892_22410	1021965..1023440 [+], 1476	541870633	T6SS/protein (ImpC/EvpB family, DUF877) VasR	TssC
13	M892_22415	1023502..1023912 [+], 411	541871696	T6SS/lysozyme-related protein (DUF1316) VasS	TssE
14	M892_22420	1023923..1025671 [+], 1749	541870634	T6SS/protein (ImpG, DUF879) VasA	TssF
15	M892_22425	1025668..1026666 [+], 999	541870635	T6SS/protein (ImpH, DUF1305) VasB	TssG
16	M892_22430	1026766..1027218 [-], 453	541871697	T6SS/putative HTH-type transcriptional regulator Lrp/AsnC family
17	M892_22435	1027251..1030640 [-], 3390	541870636	T6SS/membrane protein (IcmF-like) VasK	TssM
18	M892_22440	1030668..1031972 [-], 1305	541870637	T6SS/ImpA domain protein VasL	TssA
19	M892_22445	1032595..1033194 [+], 600	541871698	T6SS/hypothetical protein (DUF820)
20	M892_22450	1033204..1034718 [+], 1515	541870638	T6SS/FHA-containing domain protein (ImpI family) VasC	Fha
21	M892_22455	1034762..1035211 [+], 450	541871699	T6SS/lipoprotein VasD	TssJ
22	M892_22460	1035223..1036548 [+], 1326	541870639	T6SS/protein (ImpJ family, DUF876) VasE	TssK
23	M892_22465	1036545..1037336 [+], 792	541870640	T6SS/T4SS outer membrane protein (ImpK, DotU family) VasF	TssL
24	M892_22470	1037440..1038360 [-], 921	541871700	transposase IS903
25	M892_22475	1038411..1038848 [-], 438	541871701	DNA-binding protein
26	M892_22480	1038941..1039426 [+], 486	541871702	hypothetical protein
27	M892_22485	1039677..1041833 [+], 2157	541871703	TonB-denpendent receptor

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

VPA1263 , VEPGS_0021, VP1388

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	M892_10090	2199433..2202012 [+], 2580	541869767	S-type Pyocin family	VPA1263
2	M892_22365	1011098..1011616 [+], 519	541870625	T6SS/hemolysin co-regulated protein Hcp	VEPGS_0021
3	M892_22335	998499..1000097 [+], 1599	541871691	hypothetical protein	VP1388

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Proteins        Genes

Homology Immunity protein list

v12G01_02260

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	M892_18605	166712..167365 [+], 654	541871355	hypothetical protein	v12G01_02260

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Proteins        Genes

N/A