I. Summary
SecReT6 ID857 insolico
StrainSalmonella enterica subsp. enterica serovar Typhimurium str. DT2
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1STMDT2_02561 (mltD)299912..301279 [-], 1368549722978membrane-bound lytic murein transglycosylase d precursor 
2STMDT2_02571 (gloB)301351..302106 [-], 7565497229797 probable hydroxyacylglutathione hydrolase 
3STMDT2_02581302141..302863 [+], 723549722980hypothetical protein 
4STMDT2_02591 (rnhA)302860..303327 [-], 468549722981ribonuclease H 
5STMDT2_02601 (dnaQ)303391..304122 [+], 732549722982DNA polymerase III epsilon subunit 
6STMDT2_02611 (sciA)304654..305709 [-], 1056549722983virulence associated protein  TssA
7STMDT2_02621 (sciB)305720..306715 [-], 996549722984virulence associated protein  TssG
8STMDT2_02631 (sciC)306712..308595 [-], 1884549722985virulence associated protein  TssF
9STMDT2_02641 (sciD)308611..309105 [-], 495549722986virulence associated protein  TssE
10STMDT2_02651 (sciE)309102..309926 [-], 825549722987virulence associated protein  TagJ
11STMDT2_02661 (sciF)309913..310815 [-], 903549722988virulence associated protein 
12STMDT2_02671 (sciG)311183..313822 [+], 2640549722989virulence associated protein  TssH
13STMDT2_02681 (sciH)313922..314464 [+], 543549722990virulence associated protein  TssB
14STMDT2_02691 (sciI)314488..315981 [+], 1494549722991virulence associated protein  TssC
15STMDT2_02701315996..316154 [+], 159549722992hypothetical protein 
16STMDT2_02711316167..316613 [+], 447549722993hypothetical protein 
17STMDT2_02721 (sciK)316867..317352 [+], 486549722994virulence associated protein  TssD
18STMDT2_02731317657..318142 [+], 486549722995hypothetical protein  STM0277 (e)
19STMDT2_02741318127..318510 [+], 384549722996hypothetical protein  STM0278 (i)
20STMDT2_02751 (sciK1)318653..319138 [+], 486549722997virulence associated protein  TssD
21STMDT2_02761 (sciN)319205..319741 [+], 537549722998hypothetical protein  TssJ
22STMDT2_02771 (sciO)319745..321088 [+], 1344549722999virulence associated protein  TssK
23STMDT2_02781 (sciP)321085..322389 [+], 1305549723000putative membrane protein, virulence associated protein  TssL
24STMDT2_02791 (sciQ)322394..323167 [+], 774549723001putative membrane protein, virulence associated protein 
25STMDT2_02801323370..323801 [+], 432549723002hypothetical protein 
26STMDT2_02811 (sciS)323835..327704 [+], 3870549723003probable IcmF-related integral membrane ATP-binding protein, virulence associated protein  TssM
27STMDT2_02821327704..328492 [+], 789549723004hypothetical protein 
28STMDT2_02831 (sciU)328489..328905 [+], 417549723005virulence associated,probable secreted protein 
29STMDT2_02841328929..329450 [+], 522549723006conserved hypothetical pathogenicity island protein 
30STMDT2_02851 (vrgS)329847..332036 [+], 2190549723007Type VI secretion protein  TssI
31STMDT2_02861 (sciW)332060..332506 [+], 447549723008virulence associated protein 
32STMDT2_02862332519..336619 [+], 4101549723009hypothetical protein  PAAR
33STMDT2_02871336613..336876 [+], 264549723010hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
EvpC , STM0277, EvpC, STY2606, ROD_34191

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1STMDT2_02721(sciK)316867..317352 [+], 486549722994virulence associated protein EvpC
2STMDT2_02731317657..318142 [+], 486549722995hypothetical protein STM0277
3STMDT2_02751(sciK1)318653..319138 [+], 486549722997virulence associated protein EvpC
4STMDT2_234412477516..2477884 [+], 369549725031hypothetical protein STY2606
5STMDT2_302513248713..3249198 [-], 486549725694hypothetical protein ROD_34191

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Proteins        Genes

Homology Immunity protein list
STM0278, STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1STMDT2_02741318127..318510 [+], 384549722996hypothetical protein STM0278
2STMDT2_234512477884..2478402 [+], 519549725032putative lipoprotein STY2607

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Proteins        Genes