SecReT6
I. Summary
SecReT6 ID860 insolico
StrainSalmonella enterica subsp. enterica serovar Typhimurium DT104
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_022569
Location304664..332061
Comment
FunctionN/A
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121111111
ComponentTssGTssJTssKTssM
Number0111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1DT104_02591 (mltD)299922..301289 [-], 1368550899675membrane-bound lytic murein transglycosylase d precursor 
2DT104_02601 (gloB)301361..302116 [-], 756550899676probable hydroxyacylglutathione hydrolase 
3DT104_02611302151..302873 [+], 723550899677conserved hypothetical protein 
4DT104_02621 (rnhA)302870..303337 [-], 468550899678Ribonuclease H 
5DT104_02631 (dnaQ)303401..304132 [+], 732550899679DNA polymerase III epsilon subunit 
6DT104_02641304664..305719 [-], 1056550899680conserved hypothetical pathogenicity island protein  TssA
7DT104_02661 (sciC)306722..308605 [-], 1884550899681uncharacterized type IV secretion system SciC protein  TssF
8DT104_02671 (sciD)308621..309115 [-], 495550899682type vi secretion system lysozyme-like SciD protein  TssE
9DT104_02681 (sciE)309112..309936 [-], 825550899683type IV secretion system SciE protein  TagJ
10DT104_02691 (sciF)309923..310825 [-], 903550899684tyep IV secretion system Scif protein 
11DT104_02701 (sciG)311193..313832 [+], 2640550899685type IV secretion system SciG protein  TssH
12DT104_02711 (sciH)313932..314474 [+], 543550899686type IV secretion system SciH protein  TssB
13DT104_02721 (sciI)314498..316006 [+], 1509550899687type IV secretion system SciI protein  TssC
14DT104_02731316021..316179 [+], 159550899688invasol SirA 
15DT104_02741 (sciJ)316192..316638 [+], 447550899689type VI secretion system SciJ protein flags: precursor 
16DT104_02751 (sciK)316892..317377 [+], 486550899690type IV secretion system SciK protein  TssD
17DT104_02761 (sciL)317682..318167 [+], 486550899691type IV secretion system SciL protein  STM0277 (e)
18DT104_02771318152..318535 [+], 384550899692putative periplasmic protein  STM0278 (i)
19DT104_02781 (sciM)318678..319163 [+], 486550899693type IV secretion system hemolysin-coregulated SciM protein  TssD
20DT104_02791 (sciN)319230..319766 [+], 537550899694type IV secretion system SciN protein flags: precursor  TssJ
21DT104_02801 (sciO)319770..321113 [+], 1344550899695tyep IV secretion SciO protein  TssK
22DT104_02811 (sciP)321110..322414 [+], 1305550899696type IV secretion system SciP protein  TssL
23DT104_02821 (sciQ)322419..323192 [+], 774550899697putative membrane protein, virulence associated SciQ protein 
24DT104_02831 (sciR)323395..323826 [+], 432550899698shiga-like toxin a subunit, type VI secretion system SciR protein flags: precursor 
25DT104_02841 (sciS)323860..327729 [+], 3870550899699putative icmf-related integral membrane atp-binding protein, virulence associated SciS protein  TssM
26DT104_02851 (sciT)327729..328517 [+], 789550899700putative cytoplasmic SciT protein 
27DT104_02861 (sciU)328514..328930 [+], 417550899701uncharacterized SciU protein 
28DT104_02871328954..329475 [+], 522550899702conserved hypothetical pathogenicity island protein 
29DT104_02866328957..329475 [+], 519550899703SPI6-associated protein, partial 
30DT104_02881 (vgrG)329872..332061 [+], 2190550899704VgrG protein  TssI
31DT104_02891 (sciW)332085..332531 [+], 447550899705SciW protein 
32DT104_02901332550..334076 [+], 1527550899706rhs1 protein flags: fragment  PAAR
33DT104_02911333973..334554 [+], 582550899707putative rhs-family protein 
34DT104_02921 (sciX)334548..334994 [+], 447550899708SciX protein 
35DT104_02931 (sciY)335557..335994 [+], 438550899709SciY protein 
36DT104_02941336047..336322 [-], 276550899710hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
EvpC , STM0277, EvpC, STY2606, ROD_34191

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1DT104_02751(sciK)316892..317377 [+], 486550899690type IV secretion system SciK protein EvpC
2DT104_02761(sciL)317682..318167 [+], 486550899691type IV secretion system SciL protein STM0277
3DT104_02781(sciM)318678..319163 [+], 486550899693type IV secretion system hemolysin-coregulated SciM protein EvpC
4DT104_243112554395..2554763 [+], 369550901809hypothetical protein STY2606
5DT104_312713324230..3324715 [-], 486550902491conserved hypothetical protein ROD_34191

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Proteins        Genes

Homology Immunity protein list
STM0278, STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1DT104_02771318152..318535 [+], 384550899692putative periplasmic protein STM0278
2DT104_243212554763..2555281 [+], 519550901810putative lipoprotein STY2607

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Proteins        Genes
N/A

Genomics & Bioinformatics Group in MML, SJTU