I. Summary
SecReT6 ID9 experimental
StrainBordetella bronchiseptica RB50
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentRequired for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo; T6SS contributes to cytotoxicity of murine macrophages; T6SS is required for persistence in the murine respiratory tract; T6SS mediates increased pathology and cell recruitment in vivo; T6SS modulates a Th1 immune response
Functionanti-eukaryotic; virulence
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BB0783821685..822587 [-], 90333599772hypothetical protein 
2BB0784822584..824221 [-], 163833599773type II secretion system protein 
3BB0785824235..824999 [-], 76533599774hypothetical protein 
4BB0786824996..825595 [-], 60033599775hypothetical protein 
5BB0787825621..826130 [-], 51033599776hypothetical protein 
6BB0788826127..827497 [-], 137133599777hypothetical protein 
7BB0789827502..828008 [-], 50733599778hypothetical protein 
8BB0790828015..828809 [-], 79533599779type II secretion system protein 
9BB0791 (pilT)828844..829884 [-], 104133599780twitching mobility protein 
10BB0792 (gspO)830131..830958 [+], 82833599781type 4 prepilin-like proteins leader peptide processing enzyme 
11BB0793 (vrgS)831107..833470 [+], 236433599782hypothetical protein  TssI
12BB0794833487..833900 [+], 41433599783hypothetical protein 
13BB0795833897..836521 [+], 262533599784hypothetical protein 
14BB0796836511..837572 [+], 106233599785hypothetical protein 
15BB0797837603..838511 [+], 90933599786hypothetical protein 
16BB0798838552..839112 [+], 56133599787hypothetical protein 
17BB0799839515..840564 [+], 105033599788hypothetical protein  TssA
18BB0800840607..841170 [+], 56433599789hypothetical protein  TssB
19BB0801841192..842694 [+], 150333599790hypothetical protein  TssC
20BB0802842770..843237 [+], 46833599791hypothetical protein  TssD
21BB0803843287..844096 [+], 81033599792hypothetical protein  TagJ
22BB0804844093..844611 [+], 51933599793hypothetical protein  TssE
23BB0805844611..846524 [+], 191433599794hypothetical protein  TssF
24BB0806846559..847218 [+], 66033599795hypothetical protein 
25BB0807847215..848309 [+], 109533599796hypothetical protein  TssG
26BB0808848306..848839 [+], 53433599797hypothetical protein 
27BB0809848829..849206 [+], 37833599798hypothetical protein 
28BB0810849230..851839 [+], 261033599799ATPase  TssH
29BB0811851938..852738 [-], 80133599800hypothetical protein  Fha
30BB0812852766..853161 [-], 39633599801lipoprotein 
31BB0813853426..853968 [+], 54333599802lipoprotein  TssJ
32BB0814854014..855348 [+], 133533599803hypothetical protein  TssK
33BB0815855369..856649 [+], 128133599804hypothetical protein  TssL
34BB0816856646..860251 [+], 360633599805hypothetical protein  TssM
35BB0817860248..860982 [+], 73533599806hypothetical protein 
36BB0818861007..862185 [+], 117933599807hypothetical protein 
37BB0819862283..863449 [+], 116733599808calcium/proton antiporter 
38BB0820863623..865035 [+], 141333599809lipoprotein 
39BB0821865043..868006 [-], 296433599810autotransporter 
40BB0822868456..869934 [+], 147933599811phospholipase D 
41BB0823 (modD)869941..871050 [-], 111033599812molybdenum transport ATP-binding protein 
42BB0824 (modC)871062..871742 [-], 68133599813molybdenum transport system permease 
43BB0825 (modB)871764..872519 [-], 75633599814molybdate ABC transporter substrate-binding protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

(1) Weyrich LS et al. (2012). A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo. PLoS One. 7(10):e45892. [PudMed:23071529] experimental
(2) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation