SecReT6
SecReT6 ID905 experimental
StrainEscherichia coli strain TW-XM
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionKF678350
Location1..25901
CommentT6SS2-associated mutants only presented a significant decrease in the adherence and invasion of mice brain microvascular endothelial cells (BMEC) bEnd.3 and brain tissue of duck infection model.
Functionanti-eukaryotic; effector translocation
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121121211
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1- (xmtA)1..480 [-], 480611963703Hcp-like protein  TssD
2- (xmtB)498..1940 [-], 1443611963704XmtB  TssA
3- (xmtC)1867..5334 [-], 3468611963705IcmF-like protein  TssM
4- (xmtD)5414..6856 [-], 1443611963706XmtD  TssA
5- (xmtE)6932..7570 [-], 639611963707XmtE 
6- (xmtF)7618..10377 [-], 2760611963708putative ATP-dependent Clp protease  TssH
7- (xmtG)10387..11151 [-], 765611963709XmtG  TssL
8- (xmtH)11156..12502 [-], 1347611963710XmtH  TssK
9- (xmtI)12505..13029 [-], 525611963711XmtI  TssJ
10- (xmtJ)13026..14306 [-], 1281611963712XmtJ  Fha
11- (xmtK)14323..15372 [-], 1050611963713XmtK  TssG
12- (xmtL)15336..17042 [-], 1707611963714XmtL  TssF
13- (xmtM)17183..17608 [-], 426611963715XmtM  TssE
14- (xmtN)17613..18140 [-], 528611963716XmtN  TssC
15- (xmtO)18334..19098 [-], 765611963717XmtO  TssC
16- (xmtP)19121..19624 [-], 504611963718XmtP  TssB
17- (xmtQ)20095..20253 [-], 159611963719hypothetical protein 
18- (xmtR)20330..20848 [+], 519611963720Hcp-like protein  TssD
19- (xmtS)21069..23051 [+], 1983611963721XmtS  TssI
20- (xmtT)23158..24204 [+], 1047611963722hypothetical protein 
21- (xmtU)24197..25636 [+], 1440611963723hypothetical protein  PAAR
22- (xmtV)25611..25901 [+], 291611963724hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
   Hcp2 (AHW84519), xmtA, xmtR(Hcp2B)
Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
(1) Ma J et al. (2014). Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972] experimental
 
experimental This literature contains experimental investigation