SecReT6 ID	905
Strain	Escherichia coli strain TW-XM
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	KF678350
Location	1..25901
Comment	T6SS2-associated mutants only presented a significant decrease in the adherence and invasion of mice brain microvascular endothelial cells (BMEC) bEnd.3 and brain tissue of duck infection model.
Function	anti-eukaryotic; effector translocation
T6SS Type	Type i; subtype i1
Experimental investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	2	1	2	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	- (xmtA)	1..480 [-], 480	611963703	Hcp-like protein	TssD
2	- (xmtB)	498..1940 [-], 1443	611963704	XmtB	TssA
3	- (xmtC)	1867..5334 [-], 3468	611963705	IcmF-like protein	TssM
4	- (xmtD)	5414..6856 [-], 1443	611963706	XmtD	TssA
5	- (xmtE)	6932..7570 [-], 639	611963707	XmtE
6	- (xmtF)	7618..10377 [-], 2760	611963708	putative ATP-dependent Clp protease	TssH
7	- (xmtG)	10387..11151 [-], 765	611963709	XmtG	TssL
8	- (xmtH)	11156..12502 [-], 1347	611963710	XmtH	TssK
9	- (xmtI)	12505..13029 [-], 525	611963711	XmtI	TssJ
10	- (xmtJ)	13026..14306 [-], 1281	611963712	XmtJ	Fha
11	- (xmtK)	14323..15372 [-], 1050	611963713	XmtK	TssG
12	- (xmtL)	15336..17042 [-], 1707	611963714	XmtL	TssF
13	- (xmtM)	17183..17608 [-], 426	611963715	XmtM	TssE
14	- (xmtN)	17613..18140 [-], 528	611963716	XmtN	TssC
15	- (xmtO)	18334..19098 [-], 765	611963717	XmtO	TssC
16	- (xmtP)	19121..19624 [-], 504	611963718	XmtP	TssB
17	- (xmtQ)	20095..20253 [-], 159	611963719	hypothetical protein
18	- (xmtR)	20330..20848 [+], 519	611963720	Hcp-like protein	TssD
19	- (xmtS)	21069..23051 [+], 1983	611963721	XmtS	TssI
20	- (xmtT)	23158..24204 [+], 1047	611963722	hypothetical protein
21	- (xmtU)	24197..25636 [+], 1440	611963723	hypothetical protein	PAAR
22	- (xmtV)	25611..25901 [+], 291	611963724	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files

Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

Hcp2 (AHW84519), xmtA, xmtR(Hcp2B)

Homology effector (effector protein label, when available)

Homology immunity protein (immunity protein label, when available)

(1) Ma J et al. (2014). Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972]

This literature contains experimental investigation