I. Summary

SecReT6 ID	910
Strain	Flavobacterium johnsoniae UW101
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_009441
Location	3892562..3923100
Comment	A T6SS Pathway Exports Antibacterial Effectors; T6SS Mediates Interspecies Bacterial Antagonism;
Function	anti-bacterial; effector translocation
T6SS Type	Type iii
Experimental investigation has been performed on this T6SS.

II. T6SS components

Component	VgrG	ClpV	TssB	TssC	TssE	TssF	TssG	TssK	TssN
Number	1	1	1	1	1	1	1	1	1
Component	TssO	TssP	Hcp
Number	1	1	2

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	Fjoh_3252	3890555..3891481 [-], 927	146300996	anti-FecI sigma factor FecR
2	Fjoh_3253	3891596..3892153 [-], 558	146300997	ECF subfamily RNA polymerase sigma-24 factor
3	Fjoh_3254	3892562..3894397 [-], 1836	146300998	hypothetical protein	TssF
4	Fjoh_3255	3894891..3895379 [-], 489	146300999	hypothetical protein
5	Fjoh_3256	3895387..3895947 [-], 561	146301000	hypothetical protein	Fti1 (i)
6	Fjoh_3257	3895944..3897596 [-], 1653	146301001	hypothetical protein	Fte1 (e)
7	Fjoh_3258	3897690..3898187 [-], 498	146301002	hypothetical protein
8	Fjoh_3259	3898194..3899840 [-], 1647	146301003	hypothetical protein
9	Fjoh_3260	3899844..3901652 [-], 1809	146301004	Rhs element Vgr protein	VgrG
10	Fjoh_3261	3901691..3902086 [-], 396	146301005	hypothetical protein	Hcp
11	Fjoh_3262	3902237..3902623 [-], 387	146301006	hypothetical protein	Hcp
12	Fjoh_3263	3902805..3903236 [-], 432	146301007	GPW/gp25 family protein	TssE
13	Fjoh_3264	3903250..3903963 [-], 714	146301008	hypothetical protein
14	Fjoh_3265	3904022..3904549 [-], 528	146301009	hypothetical protein
15	Fjoh_3266	3904650..3906020 [-], 1371	146301010	hypothetical protein	TssC
16	Fjoh_3267	3906041..3906490 [-], 450	146301011	hypothetical protein	TssB
17	Fjoh_3268	3906545..3907057 [-], 513	146301012	hypothetical protein	TssO
18	Fjoh_3269	3907083..3908252 [-], 1170	146301013	hypothetical protein	TssK
19	Fjoh_3270	3908526..3909506 [-], 981	146301014	hypothetical protein
20	Fjoh_3271	3909608..3910762 [-], 1155	146301015	SH3 type 3 domain-containing protein
21	Fjoh_3272	3910884..3911552 [-], 669	146301016	hypothetical protein
22	Fjoh_3273	3911564..3912304 [-], 741	146301017	hypothetical protein
23	Fjoh_3274	3912310..3915042 [-], 2733	146301018	hypothetical protein	Fjoh_3274 (e)
24	Fjoh_3275	3915054..3915548 [-], 495	146301019	hypothetical protein
25	Fjoh_3276	3915601..3916674 [-], 1074	146301020	hypothetical protein
26	Fjoh_3277	3916691..3917662 [-], 972	146301021	hypothetical protein	TssN
27	Fjoh_3278	3917665..3918609 [-], 945	146301022	hypothetical protein	TssG
28	Fjoh_3279	3918593..3919216 [-], 624	146301023	NLP/P60 protein
29	Fjoh_3280	3919581..3920633 [+], 1053	146301024	PKD domain-containing protein	TssP
30	Fjoh_3281	3920641..3923100 [+], 2460	146301025	ATPase	ClpV
31	Fjoh_3282	3923199..3923477 [-], 279	146301026	hypothetical protein
32	Fjoh_3283	3923481..3925880 [-], 2400	146301027	sulfatase
33	Fjoh_3284	3925903..3927384 [-], 1482	146301028	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

Fjoh_3257 (Fte1) , Fjoh_3260, Fjoh_3262, Fjoh_3274

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	Fjoh_3257	3895944..3897596 [-], 1653	146301001	hypothetical protein (Fte1)	Fjoh_3257 (Fte1)
2	Fjoh_3260	3899844..3901652 [-], 1809	146301004	Rhs element Vgr protein	Fjoh_3260
3	Fjoh_3262	3902237..3902623 [-], 387	146301006	hypothetical protein	Fjoh_3262
4	Fjoh_3274	3912310..3915042 [-], 2733	146301018	hypothetical protein	Fjoh_3274
Data from experimental literature

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Proteins        Genes

Homology Immunity protein list

Fjoh_3256 (Fti1)

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	Fjoh_3256	3895387..3895947 [-], 561	146301000	hypothetical protein (Fti1)	Fjoh_3256 (Fti1)
Data from experimental literature

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Proteins        Genes

(1) Russell AB et al. (2014). A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism. Cell Host Microbe. 16(2):227-36. [PudMed:25070807]

This literature contains experimental investigation

This literature contains bioinformatics investigation