I. Summary

SecReT6 ID	910
Strain	Flavobacterium johnsoniae UW101
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_009441
Location	3892562..3923100
Comment	A T6SS Pathway Exports Antibacterial Effectors; T6SS Mediates Interspecies Bacterial Antagonism;
Function	anti-bacterial; effector translocation
T6SS Type	Type iii
Experimental investigation has been performed on this T6SS.

II. T6SS components

Component	VgrG	ClpV	TssB	TssC	TssE	TssF	TssG	TssK	TssN
Number	1	1	1	1	1	1	1	1	1
Component	TssO	TssP	Hcp
Number	1	1	2

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	FJOH_RS16860	3890555..3891481 [-], 927	500935482	FecR domain-containing protein
2	FJOH_RS16865	3891596..3892153 [-], 558	500935484	RNA polymerase sigma-70 factor
3	FJOH_RS16870	3892562..3894397 [-], 1836	500935486	type VI secretion system baseplate subunit TssF	TssF
4	FJOH_RS16875	3894394..3894747 [-], 354	1520340544	carboxypeptidase-like regulatory domain-containing protein
5	FJOH_RS16880	3894891..3895379 [-], 489	500935488	hypothetical protein
6	FJOH_RS16885	3895387..3895947 [-], 561	500935490	hypothetical protein	Fti1 (i)
7	FJOH_RS16890	3895944..3897596 [-], 1653	500935492	hypothetical protein	Fte1 (e)
8	FJOH_RS16895	3897690..3898187 [-], 498	500935494	hypothetical protein
9	FJOH_RS16900	3898194..3899840 [-], 1647	500935496	DUF3289 family protein
10	FJOH_RS16905	3899844..3901652 [-], 1809	500935498	type IV secretion protein Rhs	VgrG
11	FJOH_RS16910	3901691..3902086 [-], 396	500935500	hypothetical protein	Hcp
12	FJOH_RS16915	3902237..3902623 [-], 387	500935502	hypothetical protein	Hcp
13	FJOH_RS16920	3902805..3903236 [-], 432	500935504	GPW/gp25 family protein	TssE
14	FJOH_RS16925	3903250..3903963 [-], 714	500935506	hypothetical protein
15	FJOH_RS16930	3904022..3904549 [-], 528	500935508	hypothetical protein
16	FJOH_RS16935	3904650..3906020 [-], 1371	500935510	type VI secretion system contractile sheath protein TssC	TssC
17	FJOH_RS16940	3906041..3906490 [-], 450	500935512	hypothetical protein	TssB
18	FJOH_RS16945	3906545..3907057 [-], 513	500935514	hypothetical protein	TssO
19	FJOH_RS16950	3907083..3908252 [-], 1170	500935516	hypothetical protein	TssK
20	FJOH_RS16955	3908526..3909506 [-], 981	500935518	hypothetical protein
21	FJOH_RS16960	3909608..3910762 [-], 1155	500935520	SH3 domain-containing protein
22	FJOH_RS16965	3910884..3911552 [-], 669	500935522	hypothetical protein
23	FJOH_RS16970	3911564..3912304 [-], 741	500935524	hypothetical protein
24	FJOH_RS16975	3912310..3915042 [-], 2733	500935526	hypothetical protein	Fjoh_3274 (e)
25	FJOH_RS16980	3915054..3915548 [-], 495	500935528	DUF4280 domain-containing protein
26	FJOH_RS16985	3915601..3916674 [-], 1074	500935530	LysM peptidoglycan-binding domain-containing protein
27	FJOH_RS16990	3916691..3917662 [-], 972	500935532	TssN family type VI secretion system protein	TssN
28	FJOH_RS16995	3917665..3918609 [-], 945	500935534	type VI secretion system baseplate subunit TssG	TssG
29	FJOH_RS17000	3918593..3919234 [-], 642	763168155	C40 family peptidase
30	FJOH_RS17005	3919581..3920633 [+], 1053	500935538	PKD domain-containing protein	TssP
31	FJOH_RS17010	3920641..3923100 [+], 2460	500935540	ATP-dependent Clp protease ATP-binding subunit	ClpV
32	FJOH_RS17015	3923199..3923441 [-], 243	917987358	hypothetical protein
33	FJOH_RS17020	3923481..3925880 [-], 2400	500935545	arylsulfatase
34	FJOH_RS17025	3925903..3927384 [-], 1482	500935547	DUF1254 domain-containing protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

Fjoh_3257 (Fte1) , Fjoh_3260, Fjoh_3262, Fjoh_3274

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

Homology Immunity protein list

Fjoh_3256 (Fti1)

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

(1) Russell AB et al. (2014). A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism. Cell Host Microbe. 16(2):227-36. [PudMed:25070807]

This literature contains experimental investigation

This literature contains bioinformatics investigation