SecReT6
SecReT6 ID931 experimental
StrainEscherichia coli 17-2
RepliconT6SS [Browse all T6SS(s) in this replicon]
Location
Commentsci-1 gene cluster is involved in biofilm formation
Functionanti-eukaryotic; effector translocation
experimental Experimental investigation has been performed on this T6SS.

Homology Effector list
PAO262 , XmtU   Hcp   EC042_4534

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1PA0262293802..296861 [-], 306015595459hypothetical protein PAO262
2xmtU(xmtU)24197..25636 [+], 1440611963723hypothetical protein XmtU
Data from experimental literature

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Proteins        Genes

Homology Immunity protein list
XmtV

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes

Adaptors list
EC042_4550(TagA), DUF4123 domain-containing protein (IdsC), TagL

Adaptor identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
(1) Nguyen VS et al. (2015). Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody. PLoS One. 10(3):e0122187. [PudMed:25811612] experimental
(2) Zoued A et al. (2013). TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384] experimental
(3) Brunet YR et al. (2013). Imaging Type VI Secretion-Mediated Bacterial Killing. Cell Rep. 3(1):36-41. [PudMed:23291094] experimental
(4) Aschtgen MS et al. (2012). The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. Microbiologyopen. 1(1):71-82. [PudMed:22950014]
(5) Durand E et al. (2012). Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492]
(6) Felisberto-Rodrigues C et al. (2011). Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820]
(7) Aschtgen MS et al. (2010). The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall. Mol Microbiol. 75(4):886-99. [PudMed:20487285] experimental
(8) Aschtgen MS et al. (2008). SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. J Bacteriol. 190(22):7523-31. [PudMed:18805985] experimental
 
experimental This literature contains experimental investigation