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Organism: Streptomyces laurentii ATCC 31255
Accession No. of Nucleotide Sequence: FJ436358
Location of the putative gene cluster: 12047..22621
    
Thiopeptide Series, Family: series a and b, thiostrepton
Thiopeptide: thiostrepton A (A1)  
Thiopeptide genotype: Type II

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
tsrA2686..3774
-1
1089aminotransferase[NCBI] [UniProt]
tsrB3796..4626
-1
831lipase[NCBI] [UniProt]
tsrC4685..6541
-1
1857asparagine synthase[NCBI] [UniProt]
tsrD6681..7088
-1
408ester cyclase-likeType II thiopeptide-specific[NCBI] [UniProt]
tsrE7163..8449
-1
1287acyl-CoA dehydrogenase[NCBI] [UniProt]
tsrF8594..9529
-1
936methyltransferase[NCBI] [UniProt]
tsrG9600..10241
-1
642hypothetical protein[NCBI] [UniProt]
tsrH10570..10746
1
177thiostrepton propeptideprecursor peptide[NCBI] [UniProt]
tsrI11461..12054
1
594hydrolase[NCBI] [UniProt]
tsrJ12047..14848
1
2802dehydratasenosE[NCBI] [UniProt]
tsrK14845..15885
1
1041dehydratasenosD[NCBI] [UniProt]
tsrL15872..16978
1
1107unknownnosO[NCBI] [UniProt]
tsrM16975..18744
1
1770NADH oxidasenosF[NCBI] [UniProt]
tsrN18741..20579
1
1839hypothetical proteinnosH[NCBI] [UniProt]
tsrO20576..22621
1
2046cyclodehydratasenosG[NCBI] [UniProt]
tsrP22599..24023
1
1425cytochrome P450[NCBI] [UniProt]
tsrQ23999..25312
1
1314acyl-CoA synthetase[NCBI] [UniProt]
tsrR25422..26612
1
1191cytochrome P450[NCBI] [UniProt]
tsrS26603..29413
1
2811dehydratase[NCBI] [UniProt]
tsrT29430..31229
1
1800radical SAM domain-containing proteinType II thiopeptide-specific[NCBI] [UniProt]
tsrU31226..32044
1
819short-chain dehydrogenase[NCBI] [UniProt]
tsrV32391..33134
1
744hypothetical protein[NCBI] [UniProt]

View genome context of this sequence in the genome browser
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Table 2. Reference
Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]

* : Newly annotated orf that was missed in the original genome annotation at GenBank
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