Thiopeptide:thiostrepton (Series a and b)  ChemDraw eXchange file PubChem Link
Genotype:Type II (featuring the gene coding for quinalic acid moiety formation)
Synonym:bryamycin; thiactin; A-8506;
Antibiotics: Antibacterial;
Gram Nature: Gram+;
Target Organism: Staphylococcus aureus FDA 209P (MIC=0.025µg/ml);
Staphylococcus aureus CAY27701 (MRSA) (MIC=0.1µg/ml);
Streptococcus epidermidis CAY 4402 (MRSA) (MIC=0.1µg/ml);
Enterococcus faecalis CAY 04_1 (MIC=0.025µg/ml);
Enterococcus faecium CAY 09_1 (MIC=0.025µg/ml);
Enterococcus faecium CAY 09_1 (VRE) (MIC=0.013µg/ml);
Bacillus subtilis ATCC 6633 (MIC=0.025µg/ml);
Escherichia coli JCM 5491(MIC>100µg/ml);
Anticancer:Inhibit oncogenic transcription factor,FoxM1 [Bhat UG, et al.,2008]
Producer Organism:Streptomyces hawaiiensis;
Streptomyces laurentii ATCC 31255;
Streptomyces laurentii ATCC 31255;
Streptomyces azureus ETH28555;
Reference: Hang, et al. (2005). Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses. Bioorg Med Chem Lett. 15(5):1471-4. [PudMed:15713409]  
link More details
(1) thiostrepton A (A1)     thiostrepton A (A1) JEPG file thiostrepton A (A1) ChemDraw eXchange file   gene cluster experimental  gene cluster experimental 
CAS: 1393-48-2
(2) thiostrepton B     thiostrepton B JEPG file thiostrepton B ChemDraw eXchange file  
CAS: 75524-61-7

structure: Structure in JEPG file
ChemDraw eXchange file: ChemDraw eXchange file
PubChem Link: PubChem Link
gene cluster: Biosynthetic gene cluster identified
experimental: Data derived from experimental literature