Thiopeptide:nocathiacin (Series e)  ChemDraw eXchange file 
Genotype:Type I (possessing the genes encoding indolic acid side ring)
Structural Peptide:SCTTCECSCSCSS
Antibiotics: Antibacterial;
Gram Nature: Gram+;
Target Organism: Haemophilus influenzae A20191 (MIC>16µg/ml);
Escherichia coli A29522 (MIC>16µg/ml);
Bacteroides fragilis A27850 (MIC>64µg/ml);
Streptococcus pneumoniae A9585 (MIC=0.0005µg/ml);
Streptococcu pneumoniae A27881 (MIC=0.0005µg/ml);
Streptococcu pneumoniae A28272 (MIC=0.0005µg/ml);
Enterococcus faecalis A20688 (MIC=0.03µg/ml);
Enterococcus faecium A24885 (MIC=0.03µg/ml);
Enterococcus faecium (VanR) A28142 (MIC=0.03µg/ml);
Staphylococcus aureus A15090 (MIC=0.007µg/ml);
Staphylococcus aureus (MRSA) A27223 (MIC=0.007µg/ml);
Staphylococcus epidermidis A24548 (MIC=0.015µg/ml);
Staphylococcus haemolyticus A27298 (MIC=0.015µg/ml);
Moraxella catarrhalis A22344 (MIC=0.5µg/ml);
Producer Organism:Nocardia sp. ATCC 202099;
Amicolaptosis sp. ATCC 53771;
Reference: Nicolaou, et al. (2005). Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system. Angew Chem Int Ed Engl. 44(24):3736-40. [PudMed:15892095]  
link More details
(1) nocathiacin I     nocathiacin I JEPG file nocathiacin I ChemDraw eXchange file   gene cluster experimental 
CAS: 214044-52-7
(2) nocathiacin II     nocathiacin II JEPG file nocathiacin II ChemDraw eXchange file  
CAS: 256230-46-3P
(3) nocathiacin III     nocathiacin III JEPG file nocathiacin III ChemDraw eXchange file  
CAS: 256230-47-4P
(4) nocathiacin IV     nocathiacin IV JEPG file nocathiacin IV ChemDraw eXchange file  
CAS: 400650-12-6P

structure: Structure in JEPG file
ChemDraw eXchange file: ChemDraw eXchange file
PubChem Link: PubChem Link
gene cluster: Biosynthetic gene cluster identified
experimental: Data derived from experimental literature