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Homologues of NosD
#OrganismProteinFunction
 1Streptomyces actuosus ATCC 25421NosDdehydratase
 2Nocardia sp. ATCC 202099NocDdehydratase
 3Streptomyces laurentii ATCC 31255TsrKdehydratase
 4Streptomyces sioyaensis ATCC 13989SioKdehydrotase
 5Nocardiopsis sp. TFS65-07TpaLputative dehydratase
 6Streptomyces hygroscopicus 10-22CltFputative lantibiotic biosynthesis protein
 7Nonomuraea sp. Bp3714-39TpdCdehydratase
 8Nonomuraea sp. WU8817TpdCdehydratase
 9Bacillus cereus ATCC 14579BC5083lantibiotic biosynthesis protein
 10Propionibacterium acnes KPA171202PPA0860putative lanthionine biosynthesis protein
 11Catenulispora acidiphila DSM 44928Caci_4204lantibiotic biosynthesis protein
 12Catenulispora acidiphila DSM 44928Caci_3693hypothetical protein
 13Salinispora tropica CNB-440Strop_2432hypothetical protein
 14Salinispora arenicola CNS-205Sare_2587hypothetical protein
 15Streptomyces griseus subsp. griseus NBRC 13350SGR_4413putative lantibiotic biosynthesis protein
 16Thermobispora bispora DSM 43833Tbis_0551hypothetical protein
 17Sorangium cellulosum 'So ce 56'Sce9071hypothetical protein
 18Actinosynnema mirum DSM 43827Amir_3866hypothetical protein
 19Verrucosispora maris AB-18-032VAB18032_21120putative lantibiotic biosynthesis protein
 20Frankia sp. CcI3Francci3_4200hypothetical protein
 21Corynebacterium pseudotuberculosis FRC41Cpfrc_01627hypothetical protein
 22Lysinibacillus sphaericus C3-41Bsph_4011lantibiotic biosynthesis protein
 23Herpetosiphon aurantiacus ATCC 23779Haur_0923hypothetical protein
 24Clostridium cellulovorans 743BClocel_3629hypothetical protein
 25Streptomyces venezuelae ATCC 10712SVEN_5138hypothetical protein
 26Streptomyces bingchenggensis BCW-1SBI_02228lantibiotic biosynthesis protein
 27Propionibacterium acnes HL030PA1HMPREF9601_02025conserved hypothetical protein
 28Micromonospora sp. ATCC 39149MCAG_03945hypothetical protein
 29Streptomyces sp. CSSNG_06376conserved hypothetical protein
 30Streptomyces griseus XylebKG-1SACT1_4712putative lantibiotic biosynthesis protein
 31Actinomyces viscosus C505HMPREF0059_01139PE-PGRS family protein
 32Streptomyces sp. AA4SSMG_08016predicted protein
 33Streptomyces pristinaespiralis ATCC 25486SSDG_06096predicted protein
 34Bacillus cereus G9241BCE_G9241_0525lantibiotic biosynthesis protein, putative
 35Bacillus sp. B14905BB14905_21668Lantibiotic biosynthesis protein
 36Bacillus cereus NVH0597-99BC059799_0527putative lantibiotic biosynthesis protein
 37Lactobacillus gasseri JV-V03HMPREF0514_11732lantibiotic biosynthesis protein
 38Propionibacterium acnes SK187HMPREF1034_2449thiopeptide-type bacteriocin biosynthesis domain protein
 39Actinomyces sp. oral taxon 170 str. F0386HMPREF9056_02782thiopeptide-type bacteriocin biosynthesis domain protein
 40Corynebacterium pseudotuberculosis I19CpI19_1629Hypothetical protein
 41Streptomyces albus J1074SSHG_03899lantibiotic biosynthesis protein
 42Bacillus cereus BDRD-Cer4 Bcere0015_51760similar to Lantibiotic biosynthesis protein of Bacillus cereus ATCC 14579 UniRef RepID=Q815Q2_BACCR
 43Actinomadura melliaura SCC 1655ORF3unknown
 44Streptomyces sp. NRRL 30471Mur2dehydratase
 45Streptomyces laurentii ATCC 31255TsrDsimilar to lantibiotic biosynthesis protein
 46Bacillus atrophaeus 1942BATR1942_14070hypothetical protein
 47Corynebacterium ulcerans 809CULC809_01699hypothetical protein
 48Corynebacterium ulcerans BR-AD22CULC22_01777hypothetical protein
 49Streptococcus downei F0415HMPREF9176_0867thiopeptide-type bacteriocin biosynthesis domain protein
 50Lysinibacillus fusiformis ZC1BFZC1_19170hypothetical protein
 51Propionibacterium sp. 434-HC2HMPREF9948_1491thiopeptide-type bacteriocin biosynthesis domain protein
 52Streptococcus pneumoniae INV104ORFnosD
 53Streptomyces sp. ATCC 55365GetElantibiotic-type dehydratase
 54Corynebacterium pseudotuberculosis 3/99-5Cp3995_1664Hypothetical protein
 55Corynebacterium diphtheriae INCA 402CDB402_1843hypothetical protein
 56Corynebacterium diphtheriae CDCE 8392CDCE8392_1866hypothetical protein
 57Corynebacterium diphtheriae HC03CDHC03_1858hypothetical protein
 58Corynebacterium diphtheriae PW8CDPW8_1947hypothetical protein
 59Corynebacterium diphtheriae 31ACD31A_1975hypothetical protein
 60Corynebacterium diphtheriae BH8CDBH8_1950hypothetical protein
 61Corynebacterium diphtheriae C7CDC7B_1946hypothetical protein
 62Corynebacterium pseudotuberculosis 316Cp316_1663hypothetical protein
 63Corynebacterium pseudotuberculosis P54B96CpP54B96_1650hypothetical protein
 64Streptomyces chartreusis NRRL 12338SchaN1_010100008080hypothetical protein
Protein:   NosD, dehydratase
Conserved Domains
 TIGR03891, thiopep_ocin, thiopeptide biosynthesis domain
Homology analysis using profile hidden Markov models
    Construct profile HMM(s): eleven sequences of NosD homologues experimentally reported, NosD.fasta
    link HMMER3 profile HMM file: NosD.hmm
    Generate HMM-logos with link LogoMat-M
NumberSequenceMultiple Alignment by link MUSCLE
 64Fasta  DNA   Protein
(1)Yu Y et al (2009). Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 4(10):855-64. [PudMed:19678698]
(2)Ding Y et al (2010). Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst. 6(7):1180-5. [PudMed:20473441]
(3)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(4)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(5)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(6)Engelhardt K et al (2010). Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.. Appl Environ Microbiol.. 76(21):7093-101.. [PudMed:20851988]
(7)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(8)Kelly WL et al (2009). Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc. 131(12):4327-34. [PudMed:19265401]
(9)Wang J et al (2010). Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol. 76(7):2335-44. [PudMed:20154110]
(10)Wieland Brown LC et al (2009). Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 106(8):2549-53. [PudMed:19196969]
(11)Young TS et al (2011). Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proc Natl Acad Sci U S A. . [PudMed:21788474]