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Homologues of NosG
#OrganismProteinFunction
 1Streptomyces actuosus ATCC 25421NosGputative cyclodehydratase
 2Nocardia sp. ATCC 202099NocGcyclodehydratase
 3Streptomyces laurentii ATCC 31255TsrOcyclodehydratase
 4Streptomyces sioyaensis ATCC 13989SioOcyclodehydrotase
 5Nocardiopsis sp. TFS65-07TpaHputative cyclodehydratase
 6Streptomyces hygroscopicus 10-22CltBputative docking protein
 7Nonomuraea sp. Bp3714-39TpdGcyclodehydratase
 8Nonomuraea sp. WU8817TpdGcyclodehydratase
 9Bacillus cereus ATCC 14579BC5085putative cytoplasmic protein
 10Propionibacterium acnes KPA171202PPA0862hypothetical protein
 11Catenulispora acidiphila DSM 44928Caci_4207hypothetical protein
 12Catenulispora acidiphila DSM 44928Caci_3690hypothetical protein
 13Salinispora tropica CNB-440Strop_2435hypothetical protein
 14Salinispora arenicola CNS-205Sare_2590hypothetical protein
 15Streptomyces griseus subsp. griseus NBRC 13350SGR_4410hypothetical protein
 16Thermobispora bispora DSM 43833Tbis_0555hypothetical protein
 17Sorangium cellulosum 'So ce 56'Sce9072hypothetical protein
 18Actinosynnema mirum DSM 43827Amir_3864hypothetical protein
 19Verrucosispora maris AB-18-032VAB18032_21135hypothetical protein
 20Frankia sp. CcI3Francci3_4198hypothetical protein
 21Corynebacterium pseudotuberculosis FRC41Cpfrc_01624hypothetical protein
 22Lysinibacillus sphaericus C3-41Bsph_4013putative cytoplasmic protein
 23Herpetosiphon aurantiacus ATCC 23779Haur_0918hypothetical protein
 24Clostridium cellulovorans 743BClocel_3631hypothetical protein
 25Streptomyces venezuelae ATCC 10712SVEN_5136conserved hypothetical protein
 26Streptomyces bingchenggensis BCW-1SBI_02231putative cytoplasmic protein
 27Propionibacterium acnes HL030PA1HMPREF9601_02027bacteriocin biosynthesis docking scaffold, SagD family
 28Micromonospora sp. ATCC 39149MCAG_03942hypothetical protein
 29Streptomyces sp. CSSNG_06379conserved hypothetical protein
 30Streptomyces griseus XylebKG-1SACT1_4709biosynthesis docking scaffold protein, SagD family
 31Actinomyces viscosus C505HMPREF0059_01145hypothetical protein
 32Streptomyces sp. AA4SSMG_08019goadsporin biosynthetic protein
 33Streptomyces pristinaespiralis ATCC 25486SSDG_06098conserved hypothetical protein
 34Bacillus cereus G9241BCE_G9241_0523hypothetical protein cytosolic protein,putative
 35Bacillus sp. B14905BB14905_21658hypothetical protein
 36Bacillus cereus NVH0597-99BC059799_0525hypothetical protein
 37Lactobacillus gasseri JV-V03HMPREF0514_11730conserved hypothetical protein
 38Propionibacterium acnes SK187HMPREF1034_2451YcaO-like protein
 39Actinomyces sp. oral taxon 170 str. F0386HMPREF9056_02775YcaO-like family protein
 40Corynebacterium pseudotuberculosis I19CpI19_1626(ycaO)Putative uncharacterized protein ycaO
 41Streptococcus pneumoniae INV104INV104_02870unnamed protein product; Raw score 2.97
 42Streptomyces albus J1074SSHG_03896conserved hypothetical protein
 43Bacillus cereus BDRD-Cer4 Bcere0015_51740similar to Hypothetical Cytosolic Protein of Bacillus cereus ATCC 14579 UniRef RepID=Q812K3_BACCR
 44Actinomadura melliaura SCC 1655ORF6hypothetical protein
 45Streptomyces sp. NRRL 30471Mur6cyclodehydratase
 46Streptomyces laurentii ATCC 31255TsrHputative cyclodehydratase
 47Bacillus atrophaeus 1942BATR1942_14120hypothetical protein
 48Corynebacterium ulcerans 809CULC809_01696hypothetical protein
 49Corynebacterium ulcerans BR-AD22CULC22_01774hypothetical protein
 50Streptococcus downei F0415HMPREF9176_0868YcaO-like family
 51Lysinibacillus fusiformis ZC1BFZC1_19175putative cytoplasmic protein
 52Propionibacterium sp. 434-HC2HMPREF9948_1493YcaO-like family
 53Streptomyces sp. ATCC 55365GetIcyclodehydratase
 54Corynebacterium pseudotuberculosis 3/99-5Cp3995_1661Uncharacterized protein ycaO
 55Corynebacterium diphtheriae INCA 402CDB402_1840Uncharacterized conserved protein
 56Corynebacterium diphtheriae CDCE 8392CDCE8392_1863Uncharacterized conserved protein
 57Corynebacterium diphtheriae HC03CDHC03_1854Uncharacterized conserved protein
 58Corynebacterium diphtheriae PW8CDPW8_1944hypothetical protein
 59Corynebacterium diphtheriae 31ACD31A_1972hypothetical protein
 60Corynebacterium diphtheriae BH8CDBH8_1947hypothetical protein
 61Corynebacterium diphtheriae C7CDC7B_1943hypothetical protein
 62Corynebacterium pseudotuberculosis 316Cp316_1660hypothetical protein
 63Corynebacterium pseudotuberculosis P54B96CpP54B96_1647hypothetical protein
 64Weissella paramesenteroides ATCC 33313HMPREF0877_1438hypothetical protein
 65Streptomyces chartreusis NRRL 12338SchaN1_010100008070hypothetical protein
Protein:   NosG, cyclodehydratase
Conserved Domains
 PF02624, YcaO, YcaO-like family
Homology analysis using profile hidden Markov models
    Construct profile HMM(s): eleven sequences of NosG homologues experimentally reported, NosG.fasta
    link HMMER3 profile HMM file: NosG.hmm
    Generate HMM-logos with link LogoMat-M
NumberSequenceMultiple Alignment by link MUSCLE
 65Fasta  DNA   Protein
(1)Yu Y et al (2009). Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 4(10):855-64. [PudMed:19678698]
(2)Ding Y et al (2010). Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst. 6(7):1180-5. [PudMed:20473441]
(3)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(4)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(5)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(6)Engelhardt K et al (2010). Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.. Appl Environ Microbiol.. 76(21):7093-101.. [PudMed:20851988]
(7)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(8)Kelly WL et al (2009). Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc. 131(12):4327-34. [PudMed:19265401]
(9)Wang J et al (2010). Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol. 76(7):2335-44. [PudMed:20154110]
(10)Wieland Brown LC et al (2009). Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 106(8):2549-53. [PudMed:19196969]
(11)Young TS et al (2011). Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proc Natl Acad Sci U S A. . [PudMed:21788474]

State Key Laboratory of Microbial Metabolism, SJTU, China