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Homologues of NosH
#OrganismProteinFunction
 1Streptomyces actuosus ATCC 25421NosHhypothetical protein
 2Nocardia sp. ATCC 202099NocHhypothetical protein
 3Streptomyces laurentii ATCC 31255TsrNhypothetical protein
 4Streptomyces sioyaensis ATCC 13989SioNhypothetical protein
 5Nocardiopsis sp. TFS65-07TpaGTpaG
 6Streptomyces hygroscopicus 10-22CltDputative peptidase containing docking domain
 7Nonomuraea sp. Bp3714-39TpdFhypothetical protein
 8Nonomuraea sp. WU8817TpdFhypothetical protein
 9Bacillus cereus ATCC 14579BC5086putative lantibiotic biosynthesis protein
 10Catenulispora acidiphila DSM 44928Caci_4208hypothetical protein
 11Catenulispora acidiphila DSM 44928Caci_3689hypothetical protein
 12Salinispora tropica CNB-440Strop_2436hypothetical protein
 13Salinispora arenicola CNS-205Sare_2591hypothetical protein
 14Streptomyces griseus subsp. griseus NBRC 13350SGR_4409hypothetical protein
 15Thermobispora bispora DSM 43833Tbis_0554hypothetical protein
 16Verrucosispora maris AB-18-032VAB18032_21155hypothetical protein
 17Frankia sp. CcI3Francci3_4197hypothetical protein
 18Herpetosiphon aurantiacus ATCC 23779Haur_0919hypothetical protein
 19Streptomyces venezuelae ATCC 10712SVEN_5135hypothetical protein
 20Streptomyces bingchenggensis BCW-1SBI_02232group-specific protein
 21Streptomyces sp. CSSNG_06380predicted protein
 22Streptomyces griseus XylebKG-1SACT1_4708YcaO-domain protein
 23Streptomyces albus J1074SSHG_03895transcriptional activator protein
 24Bacillus cereus BDRD-Cer4 Bcere0015_51720similar to Putative lantibiotic biosynthesis protein of Bacillus cereus ATCC 14579 UniRef RepID=Q815Q0_BACCR
 25Actinomadura melliaura SCC 1655ORF7hypothetical protein
 26Streptomyces sp. NRRL 30471Mur5putative peptidase containing docking domain protein
 27Streptomyces laurentii ATCC 31255TsrGhypothetical protein
 28Streptomyces sp. ATCC 55365GetHGetH
 29Streptomyces chartreusis NRRL 12338SchaN1_010100008065hypothetical protein
Protein:   NosH, hypothetical protein
Conserved Domains
 cl14816, MoeZ/MoeB domain, This putative domain is found in the MoeZ protein and the MoeB protein. The domain has two CXXC motifs that are only partly conserved.
Homology analysis using profile hidden Markov models
    Construct profile HMM(s): eleven sequences of NosH homologues experimentally reported, NosH.fasta
    link HMMER3 profile HMM file: NosH.hmm
    Generate HMM-logos with link LogoMat-M
NumberSequenceMultiple Alignment by link MUSCLE
 29Fasta  DNA   Protein
(1)Yu Y et al (2009). Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 4(10):855-64. [PudMed:19678698]
(2)Ding Y et al (2010). Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst. 6(7):1180-5. [PudMed:20473441]
(3)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(4)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(5)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(6)Engelhardt K et al (2010). Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.. Appl Environ Microbiol.. 76(21):7093-101.. [PudMed:20851988]
(7)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(8)Kelly WL et al (2009). Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc. 131(12):4327-34. [PudMed:19265401]
(9)Wang J et al (2010). Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol. 76(7):2335-44. [PudMed:20154110]
(10)Wieland Brown LC et al (2009). Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 106(8):2549-53. [PudMed:19196969]
(11)Young TS et al (2011). Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proc Natl Acad Sci U S A. . [PudMed:21788474]