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Homologues of NosO
#OrganismProteinFunction
 1Streptomyces actuosus ATCC 25421NosOhypothetical protein
 2Nocardia sp. ATCC 202099NocOhypothetical protein
 3Streptomyces laurentii ATCC 31255TsrLunknown
 4Streptomyces sioyaensis ATCC 13989SioLhypothetical protein
 5Nocardiopsis sp. TFS65-07TpaBTpaB
 6Streptomyces hygroscopicus 10-22CltGunknown
 7Nonomuraea sp. Bp3714-39TpdDhypothetical protein
 8Nonomuraea sp. WU8817TpdDhypothetical protein
 9Bacillus cereus ATCC 14579BC5082hypothetical protein
 10Propionibacterium acnes KPA171202PPA0861hypothetical protein
 11Thermobispora bispora DSM 43833Tbis_0552hypothetical protein
 12Actinosynnema mirum DSM 43827Amir_3862hypothetical protein
 13Frankia sp. CcI3Francci3_4195hypothetical protein
 14Lysinibacillus sphaericus C3-41Bsph_4018hypothetical protein
 15Clostridium cellulovorans 743BClocel_3633hypothetical protein
 16Streptomyces venezuelae ATCC 10712SVEN_5133hypothetical protein
 17Propionibacterium acnes HL030PA1HMPREF9601_02026conserved hypothetical protein
 18Micromonospora sp. ATCC 39149MCAG_03944hypothetical protein
 19Streptomyces pristinaespiralis ATCC 25486SSDG_06100conserved hypothetical protein
 20Bacillus cereus G9241BCE_G9241_0518hypothetical protein protein
 21Bacillus sp. B14905BB14905_21633hypothetical protein
 22Bacillus cereus NVH0597-99BC059799_0520hypothetical protein
 23Lactobacillus gasseri JV-V03HMPREF0514_11733hypothetical protein
 24Propionibacterium acnes SK187HMPREF1034_2450hypothetical protein
 25Streptococcus pneumoniae INV104INV104_02850unnamed protein product; Raw score 2.95
 26Bacillus cereus BDRD-Cer4 Bcere0015_51770similar to Putative uncharacterized protein of Bacillus cereus ATCC 14579 UniRef RepID=Q815Q3_BACCR
 27Actinomadura melliaura SCC 1655ORF2unknown
 28Streptomyces sp. NRRL 30471Mur3dehydratase
 29Streptomyces laurentii ATCC 31255TsrEhypothetical protein
 30Propionibacterium sp. 434-HC2HMPREF9948_1492hypothetical protein
 31Streptomyces sp. ATCC 55365GetFputative aza-diels-alderase protein
 32Weissella paramesenteroides ATCC 33313HMPREF0877_1440hypothetical protein
 33Streptomyces chartreusis NRRL 12338SchaN1_010100008055hypothetical protein
Protein:   NosO, hypothetical protein
Conserved Domains
 -
Homology analysis using profile hidden Markov models
    Construct profile HMM(s): eleven sequences of NosO homologues experimentally reported, NosO.fasta
    link HMMER3 profile HMM file: NosO.hmm
    Generate HMM-logos with link LogoMat-M
NumberSequenceMultiple Alignment by link MUSCLE
 33Fasta  DNA   Protein
(1)Yu Y et al (2009). Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 4(10):855-64. [PudMed:19678698]
(2)Ding Y et al (2010). Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst. 6(7):1180-5. [PudMed:20473441]
(3)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(4)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(5)Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]
(6)Engelhardt K et al (2010). Isolation and characterization of the gene cluster for biosynthesis of the thiopeptide antibiotic TP-1161.. Appl Environ Microbiol.. 76(21):7093-101.. [PudMed:20851988]
(7)Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]
(8)Kelly WL et al (2009). Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc. 131(12):4327-34. [PudMed:19265401]
(9)Wang J et al (2010). Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol. 76(7):2335-44. [PudMed:20154110]
(10)Wieland Brown LC et al (2009). Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 106(8):2549-53. [PudMed:19196969]
(11)Young TS et al (2011). Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proc Natl Acad Sci U S A. . [PudMed:21788474]